Journal of Yeungnam Medical Science

Young Ho Choi

3 Articles

Docetaxel and Cisplatin Combination Chemotherapy in Patients with Advanced Head and Neck Cancer.: Sung Won Choi, Young Ho Choi, Chang Hoon Bai, Yong Dae Kim, Si Youn Song; Yeungnam Univ J Med. 2006;23(2):162-170. Published online December 31, 2006; DOI: https://doi.org/10.12701/yujm.2006.23.2.162

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Abstract PDF: BACKGROUND
Head and neck cancer is curable at early stages with local-regional therapy. However, most patients are diagnosed with advanced stage disease that requires combination therapy. The aim of this study was to determine the efficacy of docetaxel and cisplatin combination chemotherapy, in patients with advanced head and neck cancer by evaluating the response, survival and organ preservation rates. MATERIALS AND METHODS: We reviewed retrospectively the medical records of 39 patients with advanced head and neck cancer who received docetaxel and cisplatin combination chemotherapy from March 2000 to July 2004. RESULTS: The average age of the 39 patients was 53.4 (range 30 to 73 years) years and the most common primary site was the hypopharynx (23.0%). There were 36 patients who had stage IV disease and three patients with stage III disease. The overall response rate was 76.9% (30/39), including 12 complete responses (30.8%) and 18 partial responses (46.1%). The response rate based on the primary cancer and neck metastasis was 74.4% and 69.3%; the differences were not significant. Among 16 patients with laryngeal and hypopharyngeal cancer, 13 (81.2%) had their larynx preserved after chemotherapy followed by radiotherapy and a survival rate of 61.5%; three patients (18.8%) received a total laryngectomy and had a survival rate of 66.7%. The overall survival rate from the start of chemotherapy was 56.4% with a median survival of 30 months. The common toxicities observed were alopecia, vomiting, diarrhea, hepatotoxicity and anemia but they were all generally manageable. CONCLUSION: Docetaxel and cisplatin combination chemotherapy is an effective regimen with a relatively high response rate and acceptable toxicity

Clinical Characteristics and Prognostic Factors of Nasopharyngeal Cancer.: Chang Hoon Bai, Young Jung Seo, Sang Baik Ye, Young Ho Choi, Yong Dae Kim, Si Youn Song; Yeungnam Univ J Med. 2005;22(1):72-80. Published online June 30, 2005; DOI: https://doi.org/10.12701/yujm.2005.22.1.72

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Abstract PDF: BACKGROUND
Nasopharyngeal cancer is a rare disease with a relatively poor prognosis because it tends to be diagnosed at an advanced stage. The aim of this study was to establish the clinical characteristics of nasopharyngeal cancer. MATERIALS AND METHODS: The medical records of 54 patients with nasopharyngeal cancer from January 1993 to December 2002 were reviewed retrospectively. Forty one cases were male (75.9%) and thirteen were female (24.1%). The average age was of 46.9 (range 16 to 78 years) years. The majority of patients (79.6%) were diagnosed in the advanced stage. The most common complaints were a neck mass (55.5%) and the WHO type III (53.7%) was the most frequent histological type. RESULTS: The cumulative survival rate for a 5-year period was 46.5% and the T stage, N stage, pathologic type, and clinical stage were not significantly related to the survival rate. Sixteen of 54 (31.5%) cases presented with a distant metastasis of the bone, lung, brain, spine, and liver, and six cases (11.1%) presented with a locoregional recurrence. CONCLUSION: TNM staging is not appropriate for predicting survival rate of nasopharyngeal carcinoma patients. Therefore, a newer staging system, which includes new factors, is needed to predict the prognosis.

Standard Index Development for Comparing the Glomerular Number.: Yong Jin Kim, Chi Eun Lee, Kook Joo Lee, Young Ho Choi, Jung Suk Hong; Yeungnam Univ J Med. 2001;18(1):85-93. Published online June 30, 2001; DOI: https://doi.org/10.12701/yujm.2001.18.1.85

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Abstract PDF: BACKGROUND
The number of glomerulus has been considered one of the etiologic factors especially for focal segmental glomerulosclerosis. However. glomeruli are too many to calculate them correctly. Although the fractionator method has became convinced, in which they used selected sections, not whole kidney sections, with same intervals, it is also very hard to get good results. Because it is still very time-consuming and laborous work which leads to make big observers' biases. METHODS AND MATERIALS: We designed the index for glomerular number to estimate the tendency of increase or decrease of the number of it in different kidneys and which was evaluated by other conventional methods including fractionator method. Index was based upon the theory by 1\yengaard: "the number of glomerulus correlates with the weight of kidney, which is positively correlated with body weight". Calculating formula is the number of glomeruli/surface areas of cortices which contain calculated glomeruli multiplies by kidney weight/body weight. RESULTS: We applied this index to kidneys of FGS/Kist mouse and those of RFM/ Nga mouse. The former is spontaneous glomerulosclerosis modelwith heavy protein uria and renal failure and the latter is the mother side of FGS/Kist mouse but has no glomerular disease or protein uria. The number of glomerulus of FGS/Kist mouse was decreased by 30% to those of RFM/Nga mouse. CONCLUSION: This index was useful and reliable for estimating the relative glomerular number between two groups.

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